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#1 19.02.2014 15:51:42

zaitsev
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Откуда: КНУ, химфак
Здесь с 15.05.2005
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PhD in UK (руководитель русскоговорящий!)

4-year fully funded PhD scholarship at the University of Leeds and University of Sheffield
>
>NMR screening of small molecule inhibitors targeting endonuclease activity of an ERstress sensor Ire1
>
>An unfolded protein response sensor inositol-requiring enzyme 1 (Ire1)
>is one of the most attractive pharmaceutical targets for a number of
>diseases associated with an imbalance in protein homeostasis in the
>endoplasmic reticulum, including neurodegenerative diseases, diabetes, and cancers.
>Ire1 function relies on the endonuclease activity of the Ire1
>cytoplasmic domain, which cleaves two hairpin loops from mRNA of the
>XBP1 transcription factor and thus, facilitate its nonconversional
>splicing and alternative translation. A recent discovery of a new class
>of Ire1 inhibitors that can covalently bind to the Ire1 cytoplasmic
>domain and inhibit its endonuclease activity opens a new avenue for the
>design of new therapies. The proposed project will develop a methyl
>NMR- and MS-based approach for characterization of Ire1 interactions
>with small molecule inhibitors; explore how covalent inhibitors bind to
>the Ire1 cytoplasmic domain and affect its conformation; and design and
>screen a new library of
>Ire1 therapeutics using the fragment based approach.
>
>The successful candidate will spend time working in the group of Dr
>Anastasia Zhuravleva (Leeds:  protein construct design, NMR, MS) and
>Professor Beining Chen (Sheffield: computational chemistry, compound
>library design, high-throughput screening). For more information about
>our research please visit:
>http://www.astbury.leeds.ac.uk/people/staff/staffpage.php?StaffID=AZ
>http://www.chen.group.shef.ac.uk/index.html
>
>The student will be hosted in The Astbury Centre for Structural
>Molecular Biology of the University of Leeds and the Department of
>Chemistry of the University of Sheffield and will have an access to
>outstanding research infrastructure including high resolution bio-NMR
>spectroscopy (500, 600 and 800 MHz), X-ray crystallography, and
>electron microscopy as well as mass spectrometry, surface plasmon resonance and time-resolved spectroscopies.
>
>The proposed project is a part of the White Rose Studentship Network
>"Structural and Mechanistic Biology at the RNA/Ligand Interface" that
>comprises three awarded PhD projects between six PIs from the
>Universities of Leeds, Sheffield and York. This network is focused on
>fundamental mechanistic understanding of RNA-protein-ligand
>interactions using multidisciplinary biophysical, biochemical and computational approaches.
>For more details about the network
>see:
>http://www.whiterose.ac.uk/studentships/structural-and-mechanistic-biol
>ogy-at-the-rnaligand-interface
>
>Applicants must have an undergraduate- (minimum of 2:1, or equivalent)
>or masters-level degree in a related subject and must be UK or EU citizens.
>We are seeking for candidates with strong background in either
>biochemistry/molecular biology or biophysics/medicinal/computational
>chemistry. The position will start in October 2014 and the search for
>adequate candidates will be open until the position is filled. Please
>contact A.Zhuravleva@leeds.ac.uk<mailto:A.Zhuravleva@leeds.ac.uk> and
>b.chen@sheffield.ac.uk<mailto:b.chen@sheffield.ac.uk> for further details.
>
>--
>Anastasia Zhuravleva
>Lecturer in Structural Biology
>Faculty of Biological Science
>The Astbury Centre for Structural Molecular Biology University of Leeds
>Contact: Garstang Building 8.52b|+44(0) 113 34 37750

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